By Philippe Derreumaux
Alzheimer's illness is the commonest kind of senile dementia, affecting greater than 24 million humans around the world. it truly is characterized pathologically by way of abnormally excessive degrees of neurofibrillary tangles because of the buildup of tau protein in lifeless and demise neurons, and through increased numbers of senile plaques within the cortex and hippocampus of the mind. the most important component to senile plaques is a small protein of 39–43 amino acids referred to as amyloid-β (Aβ). so far, no therapy has been proven to gradual the development of sporadic and familial Alzheimer's disease.
A huge physique of facts issues, even if, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's ailment. a strong process for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and confirm the constructions of the poisonous aggregates.
This e-book presents a wide ranging view throughout fresh in vitro and in vivo experiences besides state of the art laptop simulations, designed to extend the readers' realizing of Aβ oligomerisation and fibril formation. even as, the publication delves into the pathogenesis of familial and sporadic Alzheimer's ailment on the atomic point of detail.
Written by way of best authors of their respective fields, this booklet might be beneficial to all scientists engaged on Alzheimer's disease.
Readership: basic public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's disorder, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, buildings, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse types, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
Read Online or Download Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) PDF
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Additional resources for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux